Liverpool went second in the table with victory over West Ham in a match that featured three own goals plus another strike for the in-form Luis Suarez.
The Reds took the lead when the ball ricocheted in off Guy Demel, before Mamadou Sakho scuffed in a second.
Martin Skrtel’s own goal briefly gave West Ham hope, but Suarez’s bullet header restored Liverpool’s cushion.
Kevin Nolan was sent off for a poor challenge, before Suarez’s strike deflected in off Joey O’Brien.
A day after Suarez’s national side were pitted against England in the World Cup draw , the Uruguayan provided the latest reminder of the task that will face Roy Hodgson’s defenders in Brazil.
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Oussama Assaidi scored a superb late winner as Stoke City came from behind to stun Chelsea and earn just their fourth Premier League win this season.
Andre Schurrle’s fine low shot gave the Blues the lead, but Peter Crouch’s close-range strike levelled matters.
A lovely curled effort by substitute Stephen Ireland put the Potters ahead after the break only for Schurrle to level with a magnificent half-volley.
Schurrle then hit the bar but Assaidi’s angled strike left Chelsea in third.
The gripping finale, and a home victory, seemed highly unlikely as a Blues side who could have moved within one point of leaders Arsenal dominated the first 35 minutes.
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Manchester United slumped to their second home Premier League defeat in the space of four days as Yohan Cabaye’s goal gave Newcastle a first league victory at Old Trafford since 1972.
The home side struggled to break down the Magpies, other than a flurry of chances at the start of the second half, with Patrice Evra heading against the post before the ball rebounded against Vurnon Anita’s arm.
Newcastle struck on the break when Cabaye fired home Moussa Sissoko’s cross.
Robin van Persie had a header disallowed as Manchester United tried to respond, but Newcastle held on for a famous victory which means home form that had been cause for concern for boss David Moyes is now turning into a crisis.
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Reading’s hopes of avoiding relegation suffered another massive blow as they were well beaten by a Southampton side who have all but secured safety.
The Royals, managed by former Saints boss Nigel Adkins, made a bright start but faded badly after Jay Rodriguez slid in to give Southampton the lead.
The visitors’ dominance brought further reward when Adam Lallana slotted the second past Adam Federici.
Reading rarely threatened as they slumped to a seventh successive loss.
It is a Premier League run that only the Royals’ own sequence earlier in the campaign can match this season, and one that leaves them seven points adrift of 17th-placed Wigan, who also have two games in hand.
Arsene Wenger insists Arsenal can fight back from a 3-1 deficit against Bayern Munich on Wednesday and reach the Champions League quarter-finals.
The absence of goalkeeper Wojciech Szczesny, Jack Wilshere and Bacary Sanga has also added to Arsenal’s task.
But Wenger says: “It is difficult we know that, but it is not impossible.
“The only way to make it possible is to have a real go – that’s what we’ll do. Turning up expecting to go out would be absolutely unacceptable for us.”
As well as the first-leg scoreline and a depleted squad, Bayern Munich’s formidable home record will also challenge Arsenal’s ambitions.
The German side have not conceded three goals at home since losing to Inter Milan in the Champions League two years ago. In this season’s Bundesliga campaign, Bayern have only let in 10 goals in 25 matches.
Barcelona made Champions League history by knocking out AC Milan to reach the quarter-finals.
First-half goals from Lionel Messi plus David Villa and Jordi Alba’s second-half strikes made Barca the first side to overturn a two-goal first-leg deficit without help from an away goal.
Messi scored on five minutes, adding a second just before the break after Milan’s M’Baye Niang had hit a post.
Villa then put Barca ahead before Alba sealed the win in injury time.
“We will remember this for years to come,” said Barca sporting director and former Spain goalkeeper Andoni Zubizarreta.
“Messi’s two goals put us in a strong position, Villa’s was very important and Alba gave everyone exactly what they wanted with the fourth.”
Midfielder Jack Wilshere misses Arsenal’s Champions League last-16 clash in Germany with an ankle injury.
Defender Bacary Sagna is out with knee and leg problems while striker Lukas Podolski could miss the match because of an ankle injury.
Bayern midfielder Bastian Schweinsteiger and defender Jerome Boateng are banned and Franck Ribery is ruled out with ankle ligament damage.
Fellow winger Arjen Robben has a calf strain and faces a late fitness test.
Arsenal face the difficult task of overturning a 3-1 first-leg deficit when they travel to Munich.
The Gunners endured a miserable night at Emirates Stadium, where early goals from Toni Kroos and Thomas Mueller gave Bayern control.
Lukas Podolski pulled a goal back for Arsenal in the second half but Mario Mandzukic’s scrambled third left Arsene Wenger’s team needing to score three times in Germany to have a chance of advancing to the quarter-finals.
Wenger said: “We have to have a real go without being silly.